Histoplasmosis in an off-trail Hiker receiving ustekinumab: Implications for Preventive and diagnostic strategies for patients receiving anti-IL-12/23 therapy

Histoplasmosis in an off-trail Hiker receiving ustekinumab: Implications for Preventive and diagnostic strategies for patients receiving anti-IL-12/23 therapy

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Ustekinumab, an IL-12/23 inhibitor, Carafe is an important agent in treatment of inflammatory bowel disease and psoriasis.Clinical trials have not demonstrated significantly increased infection risk with ustekinumab.We report a case of disseminated histoplasmosis in the setting of ustekinumab and methotrexate following a hike in the Catskill Mountains, a region not commonly associated with Histoplasma encapsulatum.

To our knowledge, this is the first reported case of newly acquired Birth Month Flower Necklace Gift Box histoplasmosis complicating treatment with ustekinumab.